Adaptive mechanisms controlling uterine spiral artery remodeling during the establishment of pregnancy
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چکیده
منابع مشابه
Suppression of trophoblast uterine spiral artery remodeling by estrogen during baboon pregnancy: impact on uterine and fetal blood flow dynamics.
The present study was conducted to determine the impact of suppressing trophoblast remodeling of the uterine spiral arteries by prematurely elevating estrogen levels in the first trimester of baboon pregnancy on uterine and umbilical blood flow dynamics. Uteroplacental blood flow was assessed by Doppler ultrasonography after acute administration of saline (basal state) and serotonin on days 60,...
متن کاملUterine natural killer cells initiate spiral artery remodeling in human pregnancy.
Uterine spiral artery remodeling is required for successful human pregnancy; impaired remodeling is associated with pregnancy complications, including late miscarriage, preeclampsia, and fetal growth restriction. The molecular triggers of remodeling are not known, but it is now clear that there are "trophoblast-independent" and "trophoblast-dependent" stages. Uterine natural killer (uNK) cells ...
متن کاملUterine Spiral Artery Remodeling Involves Endothelial Apoptosis Induced by Extravillous
Sandra V. Ashton, Guy St. J. Whitley, Philip R. Dash, Mark Wareing, Ian P. Crocker, Philip N. Trophoblasts Through Fas/FasL Interactions Uterine Spiral Artery Remodeling Involves Endothelial Apoptosis Induced by Extravillous Print ISSN: 1079-5642. Online ISSN: 1524-4636 Copyright © 2004 American Heart Association, Inc. All rights reserved. Greenville Avenue, Dallas, TX 75231 is published by the...
متن کاملNatural killer cells direct hemochorial placentation by regulating hypoxia-inducible factor dependent trophoblast lineage decisions.
Natural killer (NK) cells are recruited into the uterine stroma during establishment of the hemochorial placenta and are proposed regulators of uterine spiral artery remodeling. Failures in uterine spiral artery remodeling are linked to diseases of pregnancy. This prompted an investigation of the involvement of NK cells in placentation. NK cell depletion decreased the delivery of proangiogenic ...
متن کاملSuppression of Trophoblast Uterine Spiral Artery Remodeling by Estrogen During Baboon 4 Pregnancy: Impact on Uterine and Fetal Blood Flow Dynamics
34 35 The present study was conducted to determine the impact of suppressing trophoblast 36 remodeling of the uterine spiral arteries by prematurely elevating estrogen levels in the first 37 trimester of baboon pregnancy on uterine and umbilical blood flow dynamics. Uteroplacental 38 blood flow was assessed by Doppler ultrasonography after acute administration of saline (basal 39 state) and ser...
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ژورنال
عنوان ژورنال: The International Journal of Developmental Biology
سال: 2014
ISSN: 0214-6282
DOI: 10.1387/ijdb.140083ms